740 Y-P(TFA)

Research use only, not for human use.

740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.740 Y-P is a synthetic biotinylated peptide.

740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin.

740YPDGFR(TFA),PDGFR 740Y-P(TFA)

PI3K/Akt/mTOR signaling

PI3K

PI3K

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years